Wrapup: The Quick N’ Dirty Guide To SN1/SN2/E1/E2
The previous several posts dealt with an approach to solving substitution and elimination problems that can only be described as a Quick N’ Dirty Guide
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Two Types of Elimination Reactions
Like I said in the introduction to substitution reactions, organic chemistry is an empirical, experimental science. We make observations, and then try to reason backwards
Read moreRearrangement Reactions (1) – Hydride Shifts
For nucleophilic substitution, the pattern of bonds that form and break is pretty straightforward. You break C-(leaving group) and you form C-(nucleophile). A straight swap. But
Read moreIntroduction to Nucleophilic Substitution Reactions
Following up on the 4 most important patters of reactions in Org 1, and introduction to acid-base reactions, here’s the second major pattern. It’s called
Read moreWalkthrough of Substitution Reactions (1) – Introduction
Today starts a new series of posts on walking through one of the key classes of reaction in organic chemistry: substitution reactions. The goal of
Read moreTwo Types of Substitution Reactions
Chemistry is an experimental science. There is no great Ramanujan of our discipline, who, starting with a simple set of premises, could derive and predict
Read moreThe SN2 Mechanism
Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position to reveal the mechanism
Read moreWhy the SN2 Reaction Is Powerful
Having gone through the mechanism of the SN2 reaction, let’s take a second and look at why it might be useful. In nucleophilic substitution reactions,
Read moreThe SN1 Mechanism
Previously we saw that there are two important classes of nucleophilic substitution reactions, which differ in their rate laws, dependence on substitution pattern, and the
Read moreThe Conjugate Acid Is A Better Leaving Group
One of the key factors that determines whether a nucleophilic substitution reaction will happen or not is the identity of the leaving group. Previously, we’ve
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