Activating and Deactivating Groups In Electrophilic Aromatic Substitution
Quick summary on what we’ll talk about today, on activating and deactivating groups in electrophilic aromatic substitution: There’s a lot to this post, so here’s
Read moreQuick summary on what we’ll talk about today, on activating and deactivating groups in electrophilic aromatic substitution: There’s a lot to this post, so here’s
Read moreLast post in this series on reactions of aromatic groups we introduced activating and deactivating groups in Electrophilic Aromatic Substitution (EAS). We learned that electron-donating
Read moreWe’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive effects, pi donor / pi acceptor behavior, hybridization and even
Read moreIf Org 2 has an overall theme, it’s “resonance”. Today’s post has a very simple message. Atoms with lone pairs, π bonds, radicals, and carbocations can
Read moreYou’d think after five or six posts on resonance, that would be enough. But NO, friends, it just keeps going. I promise that today’s post
Read moreFour key factors that determine the importance of resonance forms in organic chemistry are: Rule #1: Minimize charges Rule #2: Full octets are favored Rule
Read moreThe weaker the base, the better the leaving group. Electron withdrawing groups make the carbonyl more electrophilic. Electron donors make the carbonyl *less* electrophilic. Carboxylic acid derivatives always protonate on carbonyl first. Steric bulk slows down reactions.
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