Quick summary on what we’ll talk about today, on activating and deactivating groups in electrophilic aromatic substitution: There’s a lot to this post, so here’sRead more
Ace Your Next Organic Chemistry Exam.
With these Downloadable PDF Study GuidesOur Study Guides
Last post in this series on reactions of aromatic groups we introduced activating and deactivating groups in Electrophilic Aromatic Substitution (EAS). We learned that electron-donatingRead more
The weaker the base, the better the leaving group. Electron withdrawing groups make the carbonyl more electrophilic. Electron donors make the carbonyl *less* electrophilic. Carboxylic acid derivatives always protonate on carbonyl first. Steric bulk slows down reactions.Read more