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Following from Adam’s last guest post on the SN1/SN2/E1/E2 (“The Leaving Group“) here is part 3 of the series! – James Step One: What isRead more
Note (from James) When my friend Adam from The Chemistry Blog offered to write a series of posts on Substitution and Elimination, I immediately saidRead more
The weaker the base, the better the leaving group. Electron withdrawing groups make the carbonyl more electrophilic. Electron donors make the carbonyl *less* electrophilic. Carboxylic acid derivatives always protonate on carbonyl first. Steric bulk slows down reactions.Read more
5 more key concepts: Carbonyls make adjacent alkyl groups more acidic, the more electrophilic the carbonyl, the more acidic its alpha protons, carbonyls activate alkenes toward nucleophilic attack, reactivity of alpha beta unsaturated carbonyls is proportional to the stability of its enolate, enolates are nucleophiles.Read more