Tosylates And Mesylates
Today we’re going to talk about a different way of making alcohols into good leaving groups – by turning them into tosylates and mesylates (“organosulfonates”). Here’s a
Read moreleaving groups
PBr3 and SOCl2
Lately we’ve been talking a lot about converting alcohols to good leaving groups [halides] [tosylates and mesylates] You might think we’d be done already, but
Read moreSimplifying the reactions of carboxylic acid derivatives (part 1)
I’ve had a fair number of emails over the past week or two from students who say that they are having a hard time keeping
Read moreGuest Post On SN1/SN2/E1/E2 (3): Step 1 – The Nucleophile
Following from Adam’s last guest post on the SN1/SN2/E1/E2 (“The Leaving Group“) here is part 3 of the series! – James Step One: What is
Read moreGuest Post on SN1/SN2/E1/E2 (2): Three And A Half Steps To Any Substitution Or Elimination Reaction
The second in a series of guest posts on SN1/SN2/E1/E2 by Chemistry Blog author and “instructor of organic chemistry at a small Midwestern liberal arts
Read moreWalkthrough of Elimination Reactions (1)
As you’ve probably noticed by now, organic chemistry is a lot different from physics. When we’re looking to predict what reaction might occur in a
Read moreComparing the E1 and SN1 Reactions
Imagine you’re starting with the alcohol on the left and you’d like to get to the alkene on the right. What bonds are formed and
Read moreIntroduction to Nucleophilic Substitution Reactions
Following up on the 4 most important patters of reactions in Org 1, and introduction to acid-base reactions, here’s the second major pattern. It’s called
Read moreThe SN2 Mechanism
Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position to reveal the mechanism
Read moreThe SN1 Mechanism
Previously we saw that there are two important classes of nucleophilic substitution reactions, which differ in their rate laws, dependence on substitution pattern, and the
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