PBr3 and SOCl2
Lately we’ve been talking a lot about converting alcohols to good leaving groups [halides] [tosylates and mesylates] You might think we’d be done already, but
Read moreinversion
The SN2 Mechanism
Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position to reveal the mechanism
Read moreReagent Friday: Thionyl Chloride (SOCl2)
In a blatant plug for the Reagent Guide and the Reagents App for iPhone, each Friday I profile a different reagent that is commonly encountered in Org 1/ Org
Read moreSOCl2 and the SNi Mechanism
Some time ago I published this post on Reagent Friday discussing the mechanism of SOCl2 converting secondary alcohols to alkyl chlorides with secondary through an
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