The E2 Mechanism
Having gone through the E1 mechanism for elimination reactions, we’ve accounted for one way in which elimination reactions can occur. However, there’s still another set
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Comparing the E1 and E2 Reactions
Now that we’ve gone through the mechanisms of the E1 and E2 reactions, let’s take a moment to look at them side by side and
Read moreThe E2 Reaction and Cyclohexane Rings
Last time we compared the E1 and E2 reactions and mentioned one of the key differences was the stereochemistry of the E2 reaction. Remember that
Read moreBulky Bases in Elimination Reactions
We’ve recently talked about Zaitsev’s rule in elimination reactions, and how the transition state leading to the more substituted alkene is lower in energy. The
Read moreComparing the E1 and SN1 Reactions
Imagine you’re starting with the alcohol on the left and you’d like to get to the alkene on the right. What bonds are formed and
Read moreWhy the SN2 Reaction Is Powerful
Having gone through the mechanism of the SN2 reaction, let’s take a second and look at why it might be useful. In nucleophilic substitution reactions,
Read moreThe 4 Major Classes of Reactions in Org 1
At least 80% of the reactions you will learn in Org 1 fall into one of these 4 categories. The sooner you can get into the habit of recognizing bond formation and breakage the better off you will be.
Read moreThe SN1, E1, and Alkene Addition Reactions All Pass Through A Carbocation Intermediate
Was going to include this in my last post but it was getting too big. Note how the SN1, E1, and alkene addition reactions all
Read moreWhat makes a good leaving group?
A leaving group is a nucleophile acting in reverse; it accepts a lone pair as the bond between it and its neighbor (usually carbon for
Read moreGrossman’s Rule
A few months ago after putting up this post on “Hidden Hydrogens, Hidden Lone Pairs, and Hidden Counterions”, commenter Stewie Griffin made me aware of
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