The Hofmann Elimination
The Hofmann Elimination is an elimination reaction of alkylammonium salts that forms C-C double bonds [pi bonds]. [note] It proceeds through a concerted E2 mechanism. In contrast with
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The Cope Elimination
The “Cope Elimination” is a reaction where an amine is oxidized to an intermediate called an “N-oxide”, which, when heated, acts as the base in
Read moreThe Williamson Ether Synthesis
In the last post, we discussed the acid-base properties of alcohols. Two posts ago, we said that acid-base reactions are often used to “set up”
Read moreTosylates And Mesylates
Today we’re going to talk about a different way of making alcohols into good leaving groups – by turning them into tosylates and mesylates (“organosulfonates”). Here’s a
Read moreElimination of Alcohols To Alkenes With POCl3
Here’s what we talk about today: more eliminations of alcohols! Note that this reagent isn’t covered in all courses, but I’ll include it here for completeness’
Read moreDeciding SN1/SN2/E1/E2 (1) – The Substrate
Having gone through the SN1, the SN2, the E1, and the E2 reactions in turn, we can now say the following: Both substitution reactions and elimination
Read moreGuest Post On SN1/SN2/E1/E2 (6): Wrapup
Part 6 of a 6 part series. Previous posts in the series: 1 2 3 4 5 – James 3 ½ Steps To Any SN1/SN2/E1/E2 Reaction: Wrap
Read moreGuest Post On SN1/SN2/E1/E2 (5) – The Solvent
For the previous posts in Adam’s series on the SN1/SN2/E1/E2 decision, see Part 1 Part 2 Part 3 and Part 4 – James Three And A Half Steps To Any
Read moreGuest Post on SN1/SN2/E1/E2 (4): The Electrophile
For the previous posts in Adam’s series on the SN1/SN2/E1/E2, see Part 1 Part 2 Part 3. – James Three And A Half Steps To
Read moreGuest Post On SN1/SN2/E1/E2 (3): Step 1 – The Nucleophile
Following from Adam’s last guest post on the SN1/SN2/E1/E2 (“The Leaving Group“) here is part 3 of the series! – James Step One: What is
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