Basicity of Amines And pKaH
How do you measure the basicity of an amine? Case in point: what’s a stronger base: pyridine or piperidine? If you said piperidine, congratulations – it is
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5 Factors That Affect Basicity of Amines
What are the most important factors that affect the basicity of amines? Previously, we’ve seen how to evaluate the basicity of amines by examining the pKa of
Read moreThe Mesomeric Effect And Aromatic Amines
We’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive effects, pi donor / pi acceptor behavior, hybridization and even
Read moreNucleophilicity of Amines
Bonus Topic – Nucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage (translation: doesn’t get tested) in many organic chemistry
Read moreCommon Mistakes with Carbonyls: Carboxylic Acids… Are Acids!
Carboxylic acids… are acids. I know that seems obvious. But it’s a near certainty that students taking Org 2 for the first time will forget
Read moreSimplifying the reactions of carboxylic acid derivatives (part 1)
I’ve had a fair number of emails over the past week or two from students who say that they are having a hard time keeping
Read moreWalkthrough of Acid Base Reactions (1)
Now that we’ve described how to figure out where the electrons are in a molecule, the factors that stabilize negative charge and positive charge, and
Read moreWalkthrough of Acid Base Reactions (2): Basicity
Last time I started writing about acid-base reactions. We looked at this list of stabilities of anions going across the topmost row of the periodic
Read moreWalkthrough of Acid-Base Reactions (3) – Acidity Trends
Let’s review what’s been talked about so far in this series on acid-base reactions: An acid base reaction involves the donation of a proton (H+)
Read moreFive Key Factors That Influence Acidity
Today we’ll talk about what’s behind the trends in acidity for different molecules and discuss the most important factors that determine these values. I’ve written
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