Introduction to Acid-Base Reactions
Following up on the 4 major classes of reactions you encounter in Org 1, let’s look at the first of those four: acid base reactions.
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Walkthrough of Substitution Reactions (1) – Introduction
Today starts a new series of posts on walking through one of the key classes of reaction in organic chemistry: substitution reactions. The goal of
Read moreThe 4 Major Classes of Reactions in Org 1
At least 80% of the reactions you will learn in Org 1 fall into one of these 4 categories. The sooner you can get into the habit of recognizing bond formation and breakage the better off you will be.
Read moreWalkthrough of Acid Base Reactions (1)
Now that we’ve described how to figure out where the electrons are in a molecule, the factors that stabilize negative charge and positive charge, and
Read moreWalkthrough of Acid Base Reactions (2): Basicity
Last time I started writing about acid-base reactions. We looked at this list of stabilities of anions going across the topmost row of the periodic
Read moreWalkthrough of Acid-Base Reactions (3) – Acidity Trends
Let’s review what’s been talked about so far in this series on acid-base reactions: An acid base reaction involves the donation of a proton (H+)
Read moreFive Key Factors That Influence Acidity
Today we’ll talk about what’s behind the trends in acidity for different molecules and discuss the most important factors that determine these values. I’ve written
Read moreWalkthrough of Acid-Base reactions (4) – pKa
So last time we went through all the different trends that affect acidity. The bottom line is that any factor which stabilizes the conjugate base
Read moreHow to Use a pKa Table
Today we’ll talk about an incredibly important skill that might take some time to grasp but pays tremendous dividends. We’ll go through the exact details of how to use a pKa table. Understanding the proper use of a pKa table will give you the ability to recognize which acid-base reactions will happen and which will not. This will come up a lot as you progress through Org 1 and Org 2. It might be helpful to go back and review some of the factors that affect acidity that were talked about earlier.
Read moreNucleophiles and Electrophiles
All through the series on understanding where electrons are, and how they flow, we’ve been talking about how the basis of chemistry is that opposite
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