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amines

Basicity of Amines And pKaH

How do you measure the basicity of an amine? Case in point: what’s a stronger base: pyridine or piperidine? If you said piperidine, congratulations – it is

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Nucleophilicity of Amines

Bonus Topic – Nucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a  lot of coverage (translation: doesn’t get tested) in many organic chemistry

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Alkylation of Amines (Sucks)

Trends in the basicity of amines provide a classic example of why chemistry is so interesting; it’s deciphering the delicate trade-offs between various general factors

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Reductive Amination

OK – so making amines through direct alkylation is generally not a great way to go. You could even say it’s crappy. So what’s the

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