Reduction of aromatic nitro groups to amino groups

by James

Description: Nitro groups can be converted into amino groups by treatment with a reducing agent such as palladium on carbon with hydrogen gas (Pd/C, H2), zinc metal with acid, or tin (Sn) with acid.

Notes: For our purposes there are no important differences between these reagents; they are all effective.



Mechanism: For the purposes of Org 1 / Org 2 the mechanism of these reactions is not that important.

For more information consult “March’s Advanced Organic Chemistry” by March and Smith for more detailed discussion of these reactions.



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Andres Vanegas

Would an iron based reagent work as well and do you need to use NaOH for the second step in the reagents with acids?


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