Amides: Properties, Synthesis, and Nomenclature
In this post, we’ll try to provide a broad overview of amides. We’ll provide a brief overview of amide nomenclature, two important properties of amides
Read moreIn this post, we’ll try to provide a broad overview of amides. We’ll provide a brief overview of amide nomenclature, two important properties of amides
Read moreHow do you measure the basicity of an amine? Case in point: what’s a stronger base: pyridine or piperidine? If you said piperidine, congratulations – it is
Read moreWhat are the most important factors that affect the basicity of amines? Previously, we’ve seen how to evaluate the basicity of amines by examining the pKa of
Read moreWe’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive effects, pi donor / pi acceptor behavior, hybridization and even
Read moreBonus Topic – Nucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage (translation: doesn’t get tested) in many organic chemistry
Read moreTrends in the basicity of amines provide a classic example of why chemistry is so interesting; it’s deciphering the delicate trade-offs between various general factors
Read moreOK – so making amines through direct alkylation is generally not a great way to go. You could even say it’s crappy. So what’s the
Read moreWe’ve seen previously that it’s hard to *usefully* build amines through the SN2 reaction, because once amines start reacting with alkyl halides, the products tend
Read moreThe azide ion (N3– ) is one of those chemical entities that just plain looks weird. Three nitrogens in a row? check Two negative charges and a positive charge,
Read moreThe Hofmann Elimination is an elimination reaction of alkylammonium salts that forms C-C double bonds [pi bonds]. [note] It proceeds through a concerted E2 mechanism. In contrast with
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