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Reaction Friday: Friedel Crafts Acylation

Today’s Reaction Friday is about the Friedel Crafts acylation of benzene and other aromatics, an important example of electrophilic aromatic substitution.

One thing I forgot to say at the bottom is that there’s several different ways of showing how the acyl halide is activated by Lewis acid – the convention I drew is common, but your textbook may vary. Also, for the final deprotonation, it’s also possible to show Cl(-) as the base to remove the proton from the carbocation, rather than the Fe-Cl bond.


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